Abstract #4727

Ubiquitous Mitochondrial Creatine Kinase Drives Malignant Creatine Metabolite Profiles in Triple-Negative Breast Cancer Models

Vinay Ayyappan¹, Caitlin Tressler¹, Menglin Cheng¹, Kanchan Sonkar¹, Ruoqing Cai¹, Michael T. McMahon^1,2, and Kristine Glunde^1,3

¹he Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Ubiquitous Mitochondrial Creatine Kinase (CKMT1) is a mitochondrial membrane protein that catalyzes the reversible conversion of creatine (Cr) to phosphocreatine (PCr). This study shows in a mouse model of triple-negative breast cancer that CKMT1-overexpression significantly increases tumor Cr and PCr levels while accelerating tumor growth. Since high CKMT1 predicts worsened survival in breast cancer patients, CKMT1 may hold promise as a potential diagnostic marker and/or treatment target whose expression can be monitored using magnetic resonance spectroscopy-detected Cr and PCr levels.

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