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Abstract #4727

Ubiquitous Mitochondrial Creatine Kinase Drives Malignant Creatine Metabolite Profiles in Triple-Negative Breast Cancer Models

Vinay Ayyappan1, Caitlin Tressler1, Menglin Cheng1, Kanchan Sonkar1, Ruoqing Cai1, Michael T. McMahon1,2, and Kristine Glunde1,3
1he Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Ubiquitous Mitochondrial Creatine Kinase (CKMT1) is a mitochondrial membrane protein that catalyzes the reversible conversion of creatine (Cr) to phosphocreatine (PCr). This study shows in a mouse model of triple-negative breast cancer that CKMT1-overexpression significantly increases tumor Cr and PCr levels while accelerating tumor growth. Since high CKMT1 predicts worsened survival in breast cancer patients, CKMT1 may hold promise as a potential diagnostic marker and/or treatment target whose expression can be monitored using magnetic resonance spectroscopy-detected Cr and PCr levels.

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