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Abstract #4728

Lymphotropic Nanoparticle-Enhanced LNMRI for Accurate Prediction of Nodal Status in Canine Head and Neck Cancer Patients

Marina Stukova1, Lynn Griffin2, Bernard Seguin2, Chad Frank2, and Natalie Julie Serkova3
1Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 2Colorado State University, Fort Collins, CO, United States, 3Radiology, University of Colorado Anschutz, Denver, CO, United States

The objective of this study was to develop an optimal iron oxide enhanced lymph node MRI protocol and robust image analysis using pre-and-post ferumoxytol T2 and T2* scans in canine patients with HNC. Since those pet patients are naturally prone to HNC, they can serve as a great translational platform for development of novel non-invasive imaging modalities for LN staging and metastasis and to guide anti-lymphangiogenic therapies. The results indicate that Ferumoxytol can be used as T2 negative contrast agent for non-invasive LN staging 48 hrs post-injection. SI normalization should be performed to a phantom or to the brain.

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