We investigate multiparametric analysis of DW- and DCE-MRI data to identify tumor subregions indicative of response in breast cancer patients undergoing neoadjuvant therapy (NAT). The analysis showed significant increases in low vascular perfusion, low cellularity subregions early in the course of NAT for patients who achieved pathological complete response and significant decreases in high vascular perfusion, high cellularity subregions on the border with parenchyma. High-dimensional analysis of multimodal MRI data can be utilized to identify subregions of response within patients and these characterizations of intratumoral heterogeneity can potentially be used to guide therapy for improved patient outcome.
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