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Abstract #4737

Accuracy and precision of preclinical renal T2 mapping using monoexponential fitting and dictionary matching methods

Carlota M. Santos1, Andreia C. Freitas1, João S. Periquito2, Paula R. Delgado2, Thoralf Niendorf2, Andreas Pohlmann2, and Rita G. Nunes1
1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Lisbon, Portugal, 2Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Parametric mapping of T2* and T2 can be used to evaluate renal blood oxygenation. Efficient T2 mapping can be performed using a multi spin-echo sequence and fitting the pixel-wise signal with a monoexponential model although known to introduce T2 bias, or by matching it to pre-computed Echo Modulation Curves, accounting for all echo pathways. A Monte Carlo simulation was performed using a numerical kidney phantom to evaluate accuracy and precision of both approaches under the influence of noise. The results demonstrated an improved T2 accuracy using the EMC method compared to monoexponential fits and low dependence on tissue-type.

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