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Abstract #4738

Comparison of tumor cellular-interstitial water exchange rates measured by DCE-MRI and diffusion time-dependent diffusion kurtosis imaging

Jin Zhang1, Karl Kiser1, Ayesha Bharadwaj Das1, Chongda Zhang1, and Sungheon Gene Kim1
1New York University School of Medicine, New York, NY, United States

Cellular-interstitial water exchange rate is an important property of tumor, potentially associated with tumor aggressiveness and treatment response. It is not trivial to measure the water exchange rate, not to mention the challenges in measuring it at a high spatial resolution. In this study, we use the 3D-UTE-GRASP method1 to generate water exchange rate maps and compare them with those measured using diffusion time-dependent diffusion kurtosis imaging2.

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