Abstract #4743

Biomechanical Response of Orthotopic Pancreatic Tumours to the Vascular Disrupting Agent ZD6126 Assessed by Magnetic Resonance Elastography

Jin Li¹, Emma L. Reeves¹, Jessica K.R. Boult¹, Craig Cummings¹, Jeffrey C. Bamber¹, Ralph Sinkus², Yann Jamin¹, and Simon P. Robinson¹

¹Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, United Kingdom, ²Division of Imaging Sciences and Biomedical Engineering, King's College London, King’s Health Partners, St. Thomas’ Hospital, London, United Kingdom

MRE-derived shear stiffness |G*| of orthotopic pancreatic tumours was sensitive to a heterogeneous treatment response induced by the vascular disrupting agent ZD6126.

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