Abstract #4744

Magnetic Resonance Elastography Predicts Early Resistance to Chemotherapy in Cancer

Rami Mustapha¹, Omar Darwish², Peter Gordon¹, Diana Cash³, Camilla Simmons³, Ralph Sinkus^2,4, and Tony Ng^1,5

¹School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom, ²Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, ³Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, ⁴Laboratory of Vascular Translational Science, UMR1148,, INSERM-University Paris Diderot, Paris, France, ⁵UCL Cancer Institute, University College London, London, United Kingdom

There is an unmet need in cancer treatment for a non-invasive technique capable of identifying drug resistance very early in the therapeutic cycle. Our team has found that tumoral tissue changes its physical aspect as a response to therapeutic stress and that MRE can detect such changes by probing tissue biomechanics. Using a chemotherapy resistant pre-clinical model, we showed that tumors solidify as a resistance mechanism. Changes in the biomechanics were then correlated with changes Collagen and Hyaluronic acid depositions, both of which can affect the immune response.

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