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Abstract #4744

Magnetic Resonance Elastography Predicts Early Resistance to Chemotherapy in Cancer

Rami Mustapha1, Omar Darwish2, Peter Gordon1, Diana Cash3, Camilla Simmons3, Ralph Sinkus2,4, and Tony Ng1,5
1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom, 2Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 3Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, 4Laboratory of Vascular Translational Science, UMR1148,, INSERM-University Paris Diderot, Paris, France, 5UCL Cancer Institute, University College London, London, United Kingdom

There is an unmet need in cancer treatment for a non-invasive technique capable of identifying drug resistance very early in the therapeutic cycle. Our team has found that tumoral tissue changes its physical aspect as a response to therapeutic stress and that MRE can detect such changes by probing tissue biomechanics. Using a chemotherapy resistant pre-clinical model, we showed that tumors solidify as a resistance mechanism. Changes in the biomechanics were then correlated with changes Collagen and Hyaluronic acid depositions, both of which can affect the immune response.

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