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Abstract #4762

3D amide proton transfer MR imaging for evaluation of hepatocellular carcinoma

Nan Wang1, Qingwei Song1, Renwang Pu1, Mingli Gao1, Lihua Chen1, Jiazheng Wang2, Zhiwei Shen2, Liangjie Lin2, and Ailian Liu1
1The First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Philips Healthcare, Beijing, China

Amide proton transfer weighted (APTw) imaging has been proved of great value in diagnoses of brain tumors, and has attracted increased interest for evaluation of abdomen diseases. Different regions of the hepatocellular carcinoma (HCC) are associated with different pathophysiological changes. The APTw-MRI was employed in this study to evaluate the protein and polypeptide molecular levels in different regions of HCC, and a significant difference was observed between APT values measured in the center of HCC and outside the tumor.

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