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Abstract #4763

Validation of accuracy of fat-referenced PRFS thermometry on activated brown adipose tissue in rat in vivo

Chuanli Cheng1, Qian Wan1, Yangzi Qiao1, Min Pan2, Changjun Tie1, Hairong Zheng1, Xin Liu1, and Chao Zou1
1Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Shenzhen, China, 2Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, China

Brown adipose tissue (BAT) is a special adipose tissue which burns fat and dissipates energy in heat. As a result, heat production capacity of BAT is considered to represent its activity directly. In this study, we aimed to evaluate the accuracy of the proposed magnetic resonance fat-referenced PRFS method on BAT in vivo in rat after activated by Norepinephrine. The preliminary results show the PRFS based thermometry can describe the temperature change in activated BAT accurately, implying that magnetic resonance thermometry (MRT) is a useful tool to characterize the BAT activity.

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