Abstract #4768

Measuring the repeatability of an automated Whole-Body Diffusion-Weighted MRI tumour segmentation approach in metastatic prostate cancer

Antonio Candito¹, Nina Tunariu¹, Richard Holbrey¹, Sebastian Schäfer², Matthew R Orton¹, David Collins¹, Fabio Zugni³, Martin O Leach¹, Matthias Baumhauer², Matthew D Blackledge¹, and Dow-Mu Koh¹

¹The Institute of Cancer Research, London, United Kingdom, ²Mint Medical, Heidelberg, Germany, ³IEO, European Institute of Oncology IRCCS, Milan, Italy

There is currently no accepted biomarker for assessing response to treatment in patients with bone disease from advanced prostate cancer (APC). Whole-Body Diffusion-Weighted-MRI (WBDWI) is emerging as a bone response biomarker in APC. However, automatic segmentation of disease from WBDWI is needed to quantify changes in WBDWI-derived biomarkers (global tumour apparent diffusion coefficient (gADC) and total tumour volume, tDV) for more reliable response assessment. We investigate the repeatability of WBMRI parameters using automatic disease delineation in APC patients.

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