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Abstract #4767

3D Isotropic Resolution Distortion-free Diffusion-Prepared Magnitude-Stabilized bSSFP Imaging at 1.5 Tesla

Yu Gao1, Ziwu Zhou1, Fei Han1, Xiaodong Zhong2, Yingli Yang1, and Peng Hu1
1Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2MR R&D Collaborations, Siemens Healthineers, Los Angeles, CA, United States

Strong spatial distortion of the DW-ssEPI sequence prevents its utilization in radiotherapy planning and treatment adaptation. In this work, a 3D diffusion-prepared magnitude-stabilized bSSFP sequence was developed and validated at 1.5T. A phase navigator was acquired during the catalyzation stage of the bSSFP readout to estimate the spatial variation of the signal phase, and a locally low-rank constrained reconstruction was developed to resolve the phase variation. The sequence was validated on a diffusion phantom and healthy volunteers. It provided submillimeter geometric fidelity and acceptable ADC accuracy, which makes it a promising candidate for treatment planning and adaptation of the brain.

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