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Abstract #4781

Comparison of ADC, IVIM and Kurtosis for differentiation of mesorectal lymph nodes in rectal cancer

Andrada Ianuș1,2, Inês Santiago3,4, Antonio Galzerano3, Paula Montesinos5, Nuno Loução5, Javier Sanchez-Gonzalez5, Daniel C. Alexander2, Celso Matos1,3, and Noam Shemesh1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2University College London, London, United Kingdom, 3Champalimaud Clinical Centre, Champalimaud Centre for the Unknown, Lisbon, Portugal, 4Nova Medical School, Lisbon, Portugal, 5Philips Healthcare Iberia, Madrid, Spain

In this study we employed a clinically feasible diffusion MRI acquisition and modelling approach at 1.5T to characterize perfusion (IVIM) and higher order diffusion (Kurtosis) properties of mesorectal lymph nodes in rectal cancer patients upon staging. The results showed that diffusivity estimated from the IVIM-Kurtosis model was the only parameter showing significant differences between benign and malignant lymph nodes. Moreover, ROC analysis evidenced improved differentiation when adding IVIM-Kurtosis to standard T2-weighted qualitative assessment by expert radiologists.

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