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Abstract #4780

Automated RECIST Measurement and Therapeutic Response Evaluation in Osteosarcoma using Diffusion Weighted MRI

Amit Mehndiratta1, Esha Badiya Kayal1, Raju Sharma2, Sameer Bakhshi3, and Devasenathipathy Kandasamy2
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Department of RadioDiagnosis, All India Institute of Medical Sciences, New Delhi, India, 3Dr. BRA Institute-Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India

Accuracy and consistency in RECIST(Response evaluation criteria in solid tumors) measurements are crucial as it directly impacts patient treatment options. Manual RECIST measurement, requiring high expertise & attention, is time-expensive, prone-to-error, operator-subjective. we propose an automated tumor segmentation and RECIST score estimation method that uses MRI image slices as input, delineates the tumor in 3D, identifies the MRI slice with maximum-tumor-burden and then measures the tumor-diameter and RECIST1.1 score for treatment response assessment. Proposed method produced reliable and reproducible automated RECIST score measurements in current bone tumor dataset and might be useful as decision support tool saving manual-effort and reading-time.

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