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Abstract #4779

Investigation of tumor grade and gadolinium enhancement by tensor-valued diffusion encoding and QTI analysis: an exploratory study of gliomas

Filip Szczepankiewicz1,2,3, Parikshit Juvekar2,4, Jan Brabec3, Pia C. Sundgren3, Markus Nilsson3, Alexandra Golby2,4, and Carl-Fredrik Westin1,2
1Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Clinical Sciences Lund, Lund University, Lund, Sweden, 4Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, United States

Diffusion MRI is sensitive to the configuration of cell structures on the microscopic level, and may be a biomarker of tumor grade. High-grade gliomas are hypothesized to be more heterogeneous on a microscopic scale, when compared to low-grade; a feature that should be reflected in the diffusional kurtosis. To explore this premise, we use tensor-valued diffusion encoding to disentangle the isotropic and anisotropic kurtosis and relate them to tumor grade and tumor tissue that is enhancing vs. non-enhancing on post-gadolinium T1 maps.

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