Abstract #4779

Investigation of tumor grade and gadolinium enhancement by tensor-valued diffusion encoding and QTI analysis: an exploratory study of gliomas

Filip Szczepankiewicz^1,2,3, Parikshit Juvekar^2,4, Jan Brabec³, Pia C. Sundgren³, Markus Nilsson³, Alexandra Golby^2,4, and Carl-Fredrik Westin^1,2

¹Radiology, Brigham and Women's Hospital, Boston, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Clinical Sciences Lund, Lund University, Lund, Sweden, ⁴Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, United States

Diffusion MRI is sensitive to the configuration of cell structures on the microscopic level, and may be a biomarker of tumor grade. High-grade gliomas are hypothesized to be more heterogeneous on a microscopic scale, when compared to low-grade; a feature that should be reflected in the diffusional kurtosis. To explore this premise, we use tensor-valued diffusion encoding to disentangle the isotropic and anisotropic kurtosis and relate them to tumor grade and tumor tissue that is enhancing vs. non-enhancing on post-gadolinium T1 maps.

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