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Abstract #4778

Can fewer diffusion-weighting data points deliver similar diagnostic performance for breast IVIM-MRI?

Kurt Li1, Archana Machireddy2, Alina Tudorica2, Brendan Moloney2, Karen Oh2, Neda Jafarian2, Savannah Partridge3, Xin Li2, and Wei Huang2
1International School of Beaverton, Aloha, OR, United States, 2Oregon Health & Science University, Portland, OR, United States, 3University of Washington, Seattle, WA, United States

The goal of this study is to compare the diagnostic performance between intravoxel incoherent motion (IVIM) imaging parameters derived from standard biexponential IVIM model fitting and those from direct calculation using only 3 b-values. This was accomplished using Monte Carlo simulations and IVIM data acquisition and analysis from 27 patients with 28 suspicious breast lesions. Results show that at low signal-to-noise ratio, the 3 b-value approach improved parameter accuracy and provided comparable diagnostic performance in benign-malignant classification compared to the biexponential fitting approach.

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