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Abstract #4791

DSC and DCE histogram analyses of diffuse glioma biomarkers, including IDH, MGMT and TERT, on differentiation 

Hanwen Zhang1, Guiwen Lv1, Wenjie He1, Yi Lei1, Fan Lin1, Mengzhu Wang2, Hong Zhang1, Lihong Liang1, and Siping Luo1
1Shenzhen Second People's Hospital, ShenZhen, China, 2Siemens Healthineers, Guangzhou, China

The molecular types of glioma including isocitrate dehydrogenase (IDH), O6-methylguanine-DNA methyltransferase (MGMT) and telomere reverse transcriptase (TERT), influence the therapeutic effect and prognosis of patients with diffuse gliomas. We combined DSC and histogram analysis of DCE methods in the diagnosis of diffuse glioma with different molecular types, in order to find biomarkers based on perfusion parameters to predict specific genotypes, and guide doctors to evaluate the prognosis of chemotherapy of patients.

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