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Abstract #4792

Estimation of Pharmacokinetic Parameters Using Three Carefully Selected DCE-MRI Timepoints for Breast Cancer Imaging

Julie C. DiCarlo1,2 and Thomas E. Yankeelov1,2,3,4
1Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, AUSTIN, TX, United States, 2Livestrong Cancer Institutes, The University of Texas at Austin, AUSTIN, TX, United States, 3Department of Biomedical Engineering, The University of Texas at Austin, AUSTIN, TX, United States, 4Department of Diagnostic Medicine, The University of Texas at Austin, AUSTIN, TX, United States

A new method based on analysis of simplicial complexes (ASC) is presented to select three time points at which to sample dynamic contrast-enhanced MRI uptake curves. The technique maps expected enhancement curve amplitudes to simplicial complex vertices and searches for the best-discriminating set of time samples. Simulation results indicate it should be possible to estimate Kety-Tofts kinetic parameters from images whose acquisition times are increased above 16 seconds per volume, in a 2-minute shorter imaging time than needed for signal enhancement ratio (SER) measurement.

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