Abstract #4792

Estimation of Pharmacokinetic Parameters Using Three Carefully Selected DCE-MRI Timepoints for Breast Cancer Imaging

Julie C. DiCarlo^1,2 and Thomas E. Yankeelov^1,2,3,4

¹Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, AUSTIN, TX, United States, ²Livestrong Cancer Institutes, The University of Texas at Austin, AUSTIN, TX, United States, ³Department of Biomedical Engineering, The University of Texas at Austin, AUSTIN, TX, United States, ⁴Department of Diagnostic Medicine, The University of Texas at Austin, AUSTIN, TX, United States

A new method based on analysis of simplicial complexes (ASC) is presented to select three time points at which to sample dynamic contrast-enhanced MRI uptake curves. The technique maps expected enhancement curve amplitudes to simplicial complex vertices and searches for the best-discriminating set of time samples. Simulation results indicate it should be possible to estimate Kety-Tofts kinetic parameters from images whose acquisition times are increased above 16 seconds per volume, in a 2-minute shorter imaging time than needed for signal enhancement ratio (SER) measurement.

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