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Abstract #4797

Breast MRI kinetic and radiomic features correlate with invasive breast cancer angiogenesis 

Jennifer Xiao1, Michael Hirano1, Daniel Hippe1, Neal Shekar 1, Mara Rendi2, Kevin Cheung3, Habib Rahbar1, and Savannah Partridge 1
1Radiology, University of Washington, Seattle, WA, United States, 2Pathology, University of Washington, Seattle, WA, United States, 3Medicine, University of Washington, Seattle, WA, United States

Although kinetics are routinely incorporated into interpretation of contrast enhanced breast MRI, there is a paucity of literature supporting the association between the pathophysiologic basis of enhancement and its histopathologic correlate. Our study investigated DCE-MRI kinetic parameters and texture features analyzed with radiomics and their correlation with microvessel density as a surrogate for tumor angiogenesis. Twenty seven patients with invasive breast cancer were included in our study. Both peak SER and washout fraction and several texture features were significantly correlated with microvessel density (p<0.01), further supporting the biologic basis of malignant enhancement on breast MRI.

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