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Abstract #4798

Active Trans-Membrane Water Cycling Reflects Metabolic Activity in Breast Cancer MRI

Wei Huang1, Brendan Moloney1, Xin Li1, Manoj K Sammi1, Alina Tudorica1, Megan L Troxell1, Karen Y Oh1, Kathleen A Kemmer1, Arpana Naik1, Aneela Afzal1, and Charles S Springer, Jr.1
1Oregon Health & Science University, Portland, OR, United States

[Shutter-speed] SS-DCE-MRI allows access to the crucial on-going cell membrane sodium pump activity previously unreachable in vivo. Literature results indicate the latter is significantly increased early in the oncogenic transformation. This suggests an approach for early cancer detection with high-resolution imaging, a very important clinical goal. Here, we analyze SS-DCE-MRI and concomitant histopathological breast cancer data obtained during neo‑adjuvant chemotherapy, with this consideration in mind. The results support the contention, but indicate a non‑invasive, non-contrast DWI method under development is likely necessary to realize this clinical potential.

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