Acute Myeloid Leukemia (AML) is the most common acute leukemia in adults. While the clinical presentation is quite uniform, it is a highly heterogeneous disease at the genetic level. Using intravital two-photon microscopy, we have previously showed that AML patient-derived samples belonging to different genetic subgroups induced a common pathologic bone marrow (BM) vascular phenotype. To understand the translational potential of our findings we have optimized DCE-MRI for the assessment of bone marrow vascular permeability upon leukaemia development.
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