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Abstract #4802

DCE-MRI for detection of leukaemia induced bone marrow vascular permeability

Ana Gomes1, Diana Passaro1, Dominique Bonnet1, and Bernard Siow1
1Francis Crick Institute, London, United Kingdom

Acute Myeloid Leukemia (AML) is the most common acute leukemia in adults. While the clinical presentation is quite uniform, it is a highly heterogeneous disease at the genetic level. Using intravital two-photon microscopy, we have previously showed that AML patient-derived samples belonging to different genetic subgroups induced a common pathologic bone marrow (BM) vascular phenotype. To understand the translational potential of our findings we have optimized DCE-MRI for the assessment of bone marrow vascular permeability upon leukaemia development.

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