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Abstract #4807

Deregulation of lipid metabolism in postmenopausal breast cancer patients using double quantum filtered correlation spectroscopy (DQF-COSY)

Sai Man Cheung1, Vasiliki Mallikourti1, Yazan Masannat2, Tanja Gagliardi3,4, Steven Heys2, and Jiabao He1
1Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, 2Breast Unit, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 3Clinical Radiology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 4Radiology, Royal Marsden Hospital, London, United Kingdom

Deregulation of lipid metabolism has been shown in BRCA1/2 genetic mutation carriers. Mammary adipose tissues in postmenopausal women are the primary sites of oestrogen production linked to tumour initiation and progression. Therefore, lipid composition in postmenopausal breast plays a key role in breast cancer monitoring and subsequent development of prevention strategies. Previous studies focused on cell or animal models and invasive lipid extraction methods, while conventional MRS is inadequate in complete lipid composition measurement. We hypothesised that lipid composition in peri-tumoural breast adipose tissue is affected by the presence of tumour in postmenopausal women, using a non-invasive 2D MRS approach.

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