Abstract #4808

2-Hydroxyglutarate detection with semi-LASER and MEGA-sLASER at 7T

Zahra Shams¹, Uzay Emir², Wybe J.M. van der Kemp¹, Dennis W.J. Klomp¹, Jannie P. Wijnen¹, and Evita Wiegers¹

¹Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²School of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, IN, United States

This study evaluates the performance of semi-LASER and MEGA-sLASER for 2-hydroxyglutarate (2-HG) detection at 7T. We compared a semi-LASER with TE of 110ms with editing of 2-HG at 4.02 ppm using MEGA-sLASER with TE of 74ms in phantoms with different concentrations of 2-HG. Both methods were able to detect 2-HG concentrations as low as 0.5mM. MEGA-sLASER provided a clean 2-HG signal. Contrary, the fact that the fitting accuracy for 2-HG in semi-LASER is similar to MEGA-sLASER promotes to choose for a semi-LASER implementation.

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