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Abstract #4808

2-Hydroxyglutarate detection with semi-LASER and MEGA-sLASER at 7T

Zahra Shams1, Uzay Emir2, Wybe J.M. van der Kemp1, Dennis W.J. Klomp1, Jannie P. Wijnen1, and Evita Wiegers1
1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2School of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, IN, United States

This study evaluates the performance of semi-LASER and MEGA-sLASER for 2-hydroxyglutarate (2-HG) detection at 7T. We compared a semi-LASER with TE of 110ms with editing of 2-HG at 4.02 ppm using MEGA-sLASER with TE of 74ms in phantoms with different concentrations of 2-HG. Both methods were able to detect 2-HG concentrations as low as 0.5mM. MEGA-sLASER provided a clean 2-HG signal. Contrary, the fact that the fitting accuracy for 2-HG in semi-LASER is similar to MEGA-sLASER promotes to choose for a semi-LASER implementation.

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