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Abstract #4809

Association of tumor metabolites with inflammation in the glioma microenvironment studied with HRMAS NMR

Selin Ekici1 and Candace C. Fleischer1
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States

Evidence suggests that inflammation and metabolic dysregulation in the tumor microenvironment are related, yet the mechanistic relationship is not well characterized. Our goal was to utilize ex vivo 1H high resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy to study the relationship between metabolism and tumor inflammation in gliomas. We observed that multiple inflammatory markers were positively associated with glutamine, glutathione, and lactate. C-reactive protein was positively associated with myo-inositol and aspartate. These results support the hypothesis that inflammation may drive metabolic changes in gliomas and supports the use of HRMAS NMR in studies of the tumor microenvironment.

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