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Abstract #4828

Accelerated T2* Mapping in prostate cancer on an MR-Linac

Wajiha Bano1, Mohammad Golbabaee2, and Andreas Wetscherek1
1Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, 2Computer Science Department, University of Bath, Bath, United Kingdom

T2* mapping can be used to characterize tumour hypoxia, which is associated with therapy resistance. We show the feasibility of fast T2* mapping in prostate cancer patients on a 1.5T MR-Linac. The undersampled data was reconstructed by combining parallel imaging and a sparsifying transform with an iterative model-based reconstruction. The method was tested on a multi-compartment phantom and two prostate cancer patients with retrospective undersampling. With the proposed method T2* maps can be acquired in under five minutes. We demonstrated the feasibility of daily quantitative MRI over the course of radiotherapy on an MR-Linac, to characterize treatment response.

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