This paper proposed a pairwise AdaBoost model in predicting the therapeutic effect of non-metastatic LARC treated with neoadjuvant chemotherapy-radiation therapy based on radiomics signatures coming from ADC maps. Compared with traditional models, the pairwise AdaBoost model has ability to enlarge the number of training samples, which is useful to improve the generalization ability of the model. The experimental results demonstrated that the pairwise AdaBoost model seems can improve the accuracy and robustness of the model in predicting the treatment effect for locally LARC treated with neoadjuvant chemotherapy-radiation therapy.
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