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Abstract #4841

Yttrium-90 Radioembolization for Hepatocellular Carcinoma: Outcome Prediction with MRI Derived Fat-Free Muscle Area

Anton Faron1, Alois M. Sprinkart1, Claus C. Pieper1, Rolf Fimmers2, Wolfgang Block1, Carsten Meyer1, Daniel Thomas1, Ulrike Attenberger1, and Julian A. Luetkens1
1Radiology, University Hospital Bonn, Bonn, Germany, 2Department of Medical Biometry, Informatics, and Epidemiology, University Hospital Bonn, Bonn, Germany

Magnetic resonance imaging (MRI) allows for body composition assessment, including determination of fat-free muscle area (FFMA). This study aimed to evaluate the prognostic value of FFMA, opportunistically measured from pre-interventional liver MRI, to predict outcome in patients receiving radioembolization (RE) for treatment of hepatocellular carcinoma (HCC). Patients with high FFMA showed significantly increased overall survival following treatment. On multivariate analysis, FFMA was an independent predictor of survival and thereby may reveal additional prognostic information in these patients. FFMA may become a promising new biomarker, since it is easy to assess from routine clinical imaging and represents a potential therapeutic target.

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