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Abstract #4842

A descriptive study to evaluate radiotherapy-related response for myxoid liposarcomas using functional MRI

Evanthia Kousi1, Christina Messiou1, Aisha Miah2, Matthew Orton1, Rick Haas3,4, Khin Thway2, Georgina Hopkinson1, Shane Zaidi2, Myles Smith2, Elizabeth Barquin2, Eleanor Moskovic2, Nikolaos Fotiadis2, Dirk Strauss2, Andrew Hayes1, and Maria A Schmidt1
1The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom, 2The Royal Marsden NHS Foundation Trust, London, United Kingdom, 3The Netherlands Cancer Institute, Amsterdam, Netherlands, 4The Leiden University Medical Center, Leiden, Netherlands

Summary: Myxoid liposarcomas (MLS) show enhanced radiotherapy response owing to their distinctive vasculature. We explore the role of functional MRI in identifying MLS response to radiotherapy.

Methods: Ten patients with histologically-proven MLS received radiotherapy. Diffusion, T2* and vascularity estimates were assessed at pre-, during and post-radiotherapy.

Results: Baseline values and post-radiotherapy changes of [Gd], IAUGC60 and Ktrans were statistically different between responders and non-responders but not ADC. Responders demonstrated statistically significant early tumour volume and post-radiotherapy T2* reductions.

Conclusion: Baseline vascularity estimates and their post-radiotherapy changes could predict MLS response. Early volume changes precede changes in MLS functionality.

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