Summary: Myxoid liposarcomas (MLS) show enhanced radiotherapy response owing to their distinctive vasculature. We explore the role of functional MRI in identifying MLS response to radiotherapy.
Methods: Ten patients with histologically-proven MLS received radiotherapy. Diffusion, T2* and vascularity estimates were assessed at pre-, during and post-radiotherapy.
Results: Baseline values and post-radiotherapy changes of [Gd], IAUGC60 and Ktrans were statistically different between responders and non-responders but not ADC. Responders demonstrated statistically significant early tumour volume and post-radiotherapy T2* reductions.
Conclusion: Baseline vascularity estimates and their post-radiotherapy changes could predict MLS response. Early volume changes precede changes in MLS functionality.