X-ray CT or MR Image-guided radiation therapy (IGRT) is routinely employed for oral cancer treatment. Enhancing tumor dose while limiting collateral damage to salivary glands is of critical importance for oral cancer patients. Here, we demonstrate the efficacy of multifunctional Theranostic nanoparticles (TNPs) for MR image guided radiation therapy in a rat xenograft model of oral cancer. These TNPs composed of Gold (Au) core and Gd(III) shell with combined X-ray and MR contrast can enable pre-procedure radiotherapy planning via T1-MR imaging, as well as enhance radiation treatment efficacy by increasing the tumor deposited radiation dose.
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