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Abstract #4843

 Magnetic Resonance Image guided radiation therapy with nanoparticles improves radiation response of Oral Tumor Xenograft

Gayatri Sharma1, Abdul K Abdul K. Parchur2, Jaidip M. Jagtap2, brian M. Fish2, Bergom Carmen 3, Michael Flister4, Meetha M. Medhora5, and Amit Joshi1,6
1Biomedical Engineering, Medical College of Wisconsin, MILWAUKEE, WI, United States, 2Medical College of Wisconsin, MILWAUKEE, WI, United States, 3Radiation Oncology, Medical College of Wisconsin, MILWAUKEE, WI, United States, 4Physiology, Medical College of Wisconsin, MILWAUKEE, WI, United States, 5Medical College of Wisconsin, Medical College of Wisconsin, MILWAUKEE, WI, United States, 6Biophysics, Medical College of Wisconsin, MILWAUKEE, WI, United States

X-ray CT or MR Image-guided radiation therapy (IGRT) is routinely employed for oral cancer treatment. Enhancing tumor dose while limiting collateral damage to salivary glands is of critical importance for oral cancer patients. Here, we demonstrate the efficacy of multifunctional Theranostic nanoparticles (TNPs) for MR image guided radiation therapy in a rat xenograft model of oral cancer. These TNPs composed of Gold (Au) core and Gd(III) shell with combined X-ray and MR contrast can enable pre-procedure radiotherapy planning via T1-MR imaging, as well as enhance radiation treatment efficacy by increasing the tumor deposited radiation dose.

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