Diffusion MRI methods to characterize tumour tissue could facilitate early assessment of radiotherapy response. In this study mouse models of human small intestine neuroendocrine tumours were irradiated externally, and post-treatment effects were studied over two weeks using VERDICT and kurtosis analysis of diffusion MRI measurements. Results showed multiple correlations between tumour treatment response and parameters estimated from the models, suggesting that a decrease of cell density and microstructural barriers early after treatment indicates a more substantial response. Both VERDICT and kurtosis analysis shows great potential for early assessment of treatment response to external radiation therapy in the studied tumour model.
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