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Abstract #4844

VERDICT and kurtosis modelling of diffusion MRI for early assessment of radiotherapy response in a model of human neuroendocrine tumour

Lukas Carl Lundholm1, Mikael Montelius1, Oscar Jalnefjord1, Emman Shubbar1, Eva Forssell-Aronsson1, and Maria Ljungberg1
1Department of Radiation Physics, Institute of Clinical Sciences, Göteborg, Sweden

Diffusion MRI methods to characterize tumour tissue could facilitate early assessment of radiotherapy response. In this study mouse models of human small intestine neuroendocrine tumours were irradiated externally, and post-treatment effects were studied over two weeks using VERDICT and kurtosis analysis of diffusion MRI measurements. Results showed multiple correlations between tumour treatment response and parameters estimated from the models, suggesting that a decrease of cell density and microstructural barriers early after treatment indicates a more substantial response. Both VERDICT and kurtosis analysis shows great potential for early assessment of treatment response to external radiation therapy in the studied tumour model.

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