Diffusion MRI methods to characterize tumour tissue could facilitate early assessment of radiotherapy response. In this study mouse models of human small intestine neuroendocrine tumours were irradiated externally, and post-treatment effects were studied over two weeks using VERDICT and kurtosis analysis of diffusion MRI measurements. Results showed multiple correlations between tumour treatment response and parameters estimated from the models, suggesting that a decrease of cell density and microstructural barriers early after treatment indicates a more substantial response. Both VERDICT and kurtosis analysis shows great potential for early assessment of treatment response to external radiation therapy in the studied tumour model.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords