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Abstract #4845

Heterogeneity analysis in T2 mapping enables highly sensitive radiotherapy response measurement and prediction in pancreatic allografts.

Michal Tomaszewski1, William Dominguez Viqueira1, Heiko Enderling2, and Robert J Gillies1
1Cancer Physiology, H. Lee Moffitt Cancer Center, Tampa, FL, United States, 2Institute of Mathematical Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, United States

Tumor response to radiotherapy (XRT) varies significantly between patients, calling for improved response quantification methods. Tumor response to fractionated XRT was quantified in a mouse model of pancreatic cancer with multiple MR sequences. Texture feature analysis of quantitative T2 maps revealed that histogram width information (Interquartile range metric) provided a more sensitive measure of XRT response than first order metrics, reflecting the structural heterogeneity increase due to necrosis, which presaged tumor volume changes. Thus, radiomic analyses of qT2 maps show significant promise for early response prediction, which will be crucial for future development of dynamic adaptive radiotherapy.

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