Abstract #4847

Evolution of the tissue sodium concentration in brain metastases undergoing stereotactical radiosurgery: a feasilbility study

Anne Adlung¹, Michaela A. U. Hoesl¹, Sherif Mohamed², Arne M. Ruder³, Frank A. Giordano³, Eva Neumaier Probst², and Lothar R. Schad¹

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Department of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ³Department of Radiation Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Brain metastases are the most common malignancy in the brain and can be caused by different primary tumors. The Sodium-SRS study is a prospective feasibility study to observe TSC changes in brain metastases around ablative stereotactical radiosurgery (SRS) treatment with 22 Gy single dose using GammaKnife. TSC was measured with 23Na MRI in two patients at three different time points. The prelimenary results showed feasibility to detect TSC dynamics in brain metastases treated with SRS, which warrants further evaluation.

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