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Abstract #4852

Dynamic Contrast Enhanced MRI Parametric Maps as Indicators of Lymph Node Radiotherapy Response in Head and Neck Cancer

Kareem Wahid1, Abdallah Mohammed1, Lisanne Van Dijk1, Sara Ahmed1, Renjie He1, Baher Elgohari1, Yao Ding2, Jihong Wang2, Stephen Lai3, and Clifton Fuller1
1Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States, 2Radiation Physics, MD Anderson Cancer Center, Houston, TX, United States, 3Head and Neck Surgery, MD Anderson Cancer Center, Houston, TX, United States

Current methodology in analyzing pathological lymph node radiotherapy response in head and neck cancer relies on qualitative visual inspection of geometrical features. A quantitative approach that takes into account dynamic changes in underlying lymph node pathology could be an important supplemental clinical tool in radiotherapy treatment planning. Herein, we investigate dynamic contrast enhanced MRI quantitative parametric maps as possible biomarker candidates for lymph node radiotherapy response by analyzing multi-timepoint images of head and neck cancer patients.

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