Abstract #4852

Dynamic Contrast Enhanced MRI Parametric Maps as Indicators of Lymph Node Radiotherapy Response in Head and Neck Cancer

Kareem Wahid¹, Abdallah Mohammed¹, Lisanne Van Dijk¹, Sara Ahmed¹, Renjie He¹, Baher Elgohari¹, Yao Ding², Jihong Wang², Stephen Lai³, and Clifton Fuller¹

¹Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States, ²Radiation Physics, MD Anderson Cancer Center, Houston, TX, United States, ³Head and Neck Surgery, MD Anderson Cancer Center, Houston, TX, United States

Current methodology in analyzing pathological lymph node radiotherapy response in head and neck cancer relies on qualitative visual inspection of geometrical features. A quantitative approach that takes into account dynamic changes in underlying lymph node pathology could be an important supplemental clinical tool in radiotherapy treatment planning. Herein, we investigate dynamic contrast enhanced MRI quantitative parametric maps as possible biomarker candidates for lymph node radiotherapy response by analyzing multi-timepoint images of head and neck cancer patients.

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