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Abstract #4853

Prospective assessment of DCE-MRI parameters associated with advanced mandibular osteoradionecrosis after IMRT of head and neck cancer

Abdallah Sherif Radwan Mohamed1, Renjie He1, Yao Ding1, Jihong Wang1, Joly Fahim1, Baher Elgohari1, Hesham Elhalawani1, Jason Johnson2, Jason Stafford3, Jim Bankson3, Mark Chambers4, Vlad Sandulache5, Clifton Fuller1, and Stephen Lai4
1Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States, 2Diagnostic imaging, MD Anderson Cancer Center, Houston, TX, United States, 3Imaging physics, MD Anderson Cancer Center, Houston, TX, United States, 4Head and Neck Surgery, MD Anderson Cancer Center, Houston, TX, United States, 5Baylor College of Medicine, Houston, TX, United States

Our aim was to characterize the quantitative DCE-MRI parameters associated with advanced mandibular osteoradionecrosis (ORN) in comparison with normal mandible. Thirty patients with advanced ORN after radiation of head and neck cancer were prospectively enrolled. Our results confirm there is a quantitatively significant higher degree of leakiness in the mandibular vasculature as measured using DCE-MRI parameters of areas affected with advanced grade of ORN versus healthy mandible. We were able to measure significant increases in quantitative parameters (3.3 fold Ktrans, 3 fold ve) compared to non-ORN mandibular bone.

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