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Abstract #4871

Lipid composition mapping in whole breast tumour using chemical shift encoded imaging

Sai Man Cheung1, Kwok Shing Chan2, Nicholas Senn1, Yazan Masannat3, Ehab Husain4, Steven Heys3, and Jiabao He1
1Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, 2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, 3Breast Unit, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 4Pathology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom

Lipid composition in breast has a major role in breast cancer prevention, with deregulation of lipid metabolism identified in BRCA1/2 genetic mutation carriers. Neoplastic tubule formation can infiltrate adipose tissue in peri-tumoural region, with low tubular differentiation indicating a poorer prognosis. Lipid composition measurement through biochemical extraction is invasive, while conventional chemical shift imaging demands an intolerably long acquisition time. Recent development in gradient-echo (GRE) based imaging allows lipid composition mapping of the whole breast in a clinically acceptable timeframe. We set out to examine the relationship between peri-tumoural lipid composition and tubule formation using GRE-based imaging in breast tumours.

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