Abstract #4881

Breast tumor response on dynamic contrast-enhanced MRI after single dose neoadjuvant partial breast irradiation

Maureen Groot Koerkamp¹, Jeanine Vasmel¹, Stefano Mandija^1,2, Marielle Philippens¹, Ramona Charaghvandi³, Maaike Moman⁴, Wouter Veldhuis⁴, Celien Vreuls⁵, Paul van Diest⁵, Arjen Witkamp⁶, Ronald Koelemij⁷, Annemiek Doeksen⁷, Thijs van Dalen⁸, Elsken van der Wall⁹, Helena Verkooijen¹⁰, Jan Lagendijk¹, Bram van Asselen¹, Desiree van den Bongard¹, and Anette Houweling¹

¹Radiotherapy, UMC Utrecht, Utrecht, Netherlands, ²Computational Imaging Group for MR diagnostic & therapy, UMC Utrecht, Utrecht, Netherlands, ³Radiotherapy, Radboudumc, Nijmegen, Netherlands, ⁴Radiology, UMC Utrecht, Utrecht, Netherlands, ⁵Pathology, UMC Utrecht, Utrecht, Netherlands, ⁶Surgical Oncology, UMC Utrecht, Utrecht, Netherlands, ⁷Surgery, St. Antonius, Utrecht, Netherlands, ⁸Surgery, Diakonessenhuis, Utrecht, Netherlands, ⁹Medical Oncology, UMC Utrecht, Utrecht, Netherlands, ¹⁰Epidemiology, UMC Utrecht, Utrecht, Netherlands

Radiologist assessment and quantitative dynamic contrast-enhanced (DCE) MRI analysis were used to determine if changes in these parameters could predict pathologic complete response to single ablative dose neoadjuvant partial breast irradiation. 3.0T DCE MRI scans in prone position were obtained pre-radiotherapy (RT), and 1 week, 2, 4, 6, and, if applicable, 8 months post-RT. Quantitative analysis showed an increase of relative enhancement 1 week after RT followed by a decrease at later time points which indicates acute tissue response and tumor regression, respectively. Both radiologist assessment (n=36) and quantitative analysis (n=27) could not predict pathologic response.

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