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Abstract #4881

Breast tumor response on dynamic contrast-enhanced MRI after single dose neoadjuvant partial breast irradiation

Maureen Groot Koerkamp1, Jeanine Vasmel1, Stefano Mandija1,2, Marielle Philippens1, Ramona Charaghvandi3, Maaike Moman4, Wouter Veldhuis4, Celien Vreuls5, Paul van Diest5, Arjen Witkamp6, Ronald Koelemij7, Annemiek Doeksen7, Thijs van Dalen8, Elsken van der Wall9, Helena Verkooijen10, Jan Lagendijk1, Bram van Asselen1, Desiree van den Bongard1, and Anette Houweling1
1Radiotherapy, UMC Utrecht, Utrecht, Netherlands, 2Computational Imaging Group for MR diagnostic & therapy, UMC Utrecht, Utrecht, Netherlands, 3Radiotherapy, Radboudumc, Nijmegen, Netherlands, 4Radiology, UMC Utrecht, Utrecht, Netherlands, 5Pathology, UMC Utrecht, Utrecht, Netherlands, 6Surgical Oncology, UMC Utrecht, Utrecht, Netherlands, 7Surgery, St. Antonius, Utrecht, Netherlands, 8Surgery, Diakonessenhuis, Utrecht, Netherlands, 9Medical Oncology, UMC Utrecht, Utrecht, Netherlands, 10Epidemiology, UMC Utrecht, Utrecht, Netherlands

Radiologist assessment and quantitative dynamic contrast-enhanced (DCE) MRI analysis were used to determine if changes in these parameters could predict pathologic complete response to single ablative dose neoadjuvant partial breast irradiation. 3.0T DCE MRI scans in prone position were obtained pre-radiotherapy (RT), and 1 week, 2, 4, 6, and, if applicable, 8 months post-RT. Quantitative analysis showed an increase of relative enhancement 1 week after RT followed by a decrease at later time points which indicates acute tissue response and tumor regression, respectively. Both radiologist assessment (n=36) and quantitative analysis (n=27) could not predict pathologic response.

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