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Abstract #4882

Tumor Characteristics of Discordant MRI Imaging and Pathology Following Neoadjuvant Chemotherapy in Non-metastatic Breast Cancer

Alexandra Besser1, Ana Rodriguez-Soto1, Helen Park2, Andrew Park2, Grace Ahn Sora2, Haydee Ojeda-Fournier1, and Rebecca Rakow-Penner2
1Radiology, University of California, San Diego, La Jolla, CA, United States, 2University of California, San Diego, La Jolla, CA, United States

For patients with non-metastatic or locally advanced breast cancer, MRI imaging is used to follow response to neoadjuvant chemotherapy (NAC) and determine treatment plan. However, MRI radiological complete response is not always concordant with pathological complete response. In a cohort of patients imaged at our institution with non-metastatic/locally advanced breast cancer, we report that 24% of post-NAC final MRI imaging is discordant with the final pathology report. We also show that many of these MRI false negatives demonstrate residual intermediate to high grade DCIS and contain microcalcifications.

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