Abstract #0002

VUDU: motion-robust, distortion-free multi-shot EPI

Jaejin Cho^1,2, Avery JL Berman^1,2, Borjan Gagoski^2,3, Congyu Liao⁴, Jason Stockmann^1,2, Jonathan R Polimeni^1,2, and Berkin Bilgic^1,2

¹Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ⁴Radiological Sciences Laboratory, Stanford University, Palo Alto, CA, United States

We introduce VUDU (Variable flip, blip-Up and -Down Undersampling) for motion-robust, distortion-free multi-shot EPI (msEPI) acquisition. VUDU uses FLEET-ordering to acquire all shots of a given slice successively before proceeding to the next slice, and employs variable flip angle (vfa) excitation to maximize the signal. Phase encoding polarities are reversed between shots to estimate and eliminate distortions, and low-rank constraint mitigates shot-to-shot inconsistencies. VUDU thus utilizes vfa-FLEET excitation and blip-up and -down acquisition (BUDA) to encode each slice in 250ms. We demonstrate VUDU with GRE, SE/diffusion contrasts in the brain, and expect that this will enable msEPI in the abdomen.

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