Abstract #0014

The power of field strength: a direct comparison of USPIO-enhanced MRI at 3 and 7T to detect suspicious lymph nodes in patients with prostate cancer

Ansje Fortuin^1,2, Sjaak van Asten¹, Andor Veltien¹, Bart Philips¹, Thomas Hambrock¹, Stephan Orzada^3,4, Harald Quick^3,5, Jelle Barentsz¹, Marnix Maas¹, and Tom Scheenen^1,3

¹Radboudumc, Nijmegen, Netherlands, ²Radiology, Ziekenhuis Gelderse Vallei, Ede, Netherlands, ³Erwin L Hahn Institute for MR Imaging, Essen, Germany, ⁴University of Heidelberg, Heidelberg, Germany, ⁵University of Duisburg-Essen, Essen, Germany

Lymph node metastases in prostate cancer patients are mainly found in normal sized lymph nodes and detection is a major challenge. USPIO-enhanced MRI with ferumoxtran-10 discriminates between normal and suspicious lymph nodes. We examined 20 prostate cancer patients with high risk of advanced disease with USPIO-enhanced MRI at 3 and at 7 Tesla, and compared the amount, the level of suspicion, and the size of lymph nodes with two readers. More, but on average not larger suspicious nodes were annotated on 7T versus 3T MRI by both readers, with less interobserver variability at 7T.

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