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Abstract #0014

The power of field strength: a direct comparison of USPIO-enhanced MRI at 3 and 7T to detect suspicious lymph nodes in patients with prostate cancer

Ansje Fortuin1,2, Sjaak van Asten1, Andor Veltien1, Bart Philips1, Thomas Hambrock1, Stephan Orzada3,4, Harald Quick3,5, Jelle Barentsz1, Marnix Maas1, and Tom Scheenen1,3
1Radboudumc, Nijmegen, Netherlands, 2Radiology, Ziekenhuis Gelderse Vallei, Ede, Netherlands, 3Erwin L Hahn Institute for MR Imaging, Essen, Germany, 4University of Heidelberg, Heidelberg, Germany, 5University of Duisburg-Essen, Essen, Germany

Lymph node metastases in prostate cancer patients are mainly found in normal sized lymph nodes and detection is a major challenge. USPIO-enhanced MRI with ferumoxtran-10 discriminates between normal and suspicious lymph nodes. We examined 20 prostate cancer patients with high risk of advanced disease with USPIO-enhanced MRI at 3 and at 7 Tesla, and compared the amount, the level of suspicion, and the size of lymph nodes with two readers. More, but on average not larger suspicious nodes were annotated on 7T versus 3T MRI by both readers, with less interobserver variability at 7T.

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