Abstract #0023

Increased Cardiac Pi in the Diabetic Heart Observed Using STEAM 31P MRS at 7T

Ladislav Valkovic^1,2, Andrew Apps¹, Jane Ellis¹, Damian J Tyler^1,3, Stefan Neubauer¹, Albrecht Ingo Schmid⁴, Oliver J Rider¹, and Christopher T Rodgers^1,5

¹Oxford Centre for Clinical Magnetic Resonance Research (OCMR), RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, ²Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ³Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, ⁴High Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, ⁵Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

Impaired cardiac energetics are characterized by a reduced phosphocreatine to adenosine-triphosphate ratio (PCr/ATP), however, changes in inorganic phosphate (Pi) may impact the Gibbs energy of ATP hydrolysis earlier in the disease process. Quantifying this in the diabetic heart may help explain latent diastolic dysfunction. Therefore, we used STEAM ³¹P-MRS at 7T to measure Pi/PCr in a type 2 diabetic (T2DM) cohort, and demonstrated an increased Pi/PCr in the diabetic human heart in comparison to healthy subjects. No correlation between PCr/ATP and Pi/PCr hints that multiple mechanisms contribute to these perturbations with candidates including impairment of CK flux and substrate inflexibility.

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