Meeting Banner
Abstract #0024

Left Ventricular Myocardial Stiffness Decreases after Stem Cell Therapy in Amyloidosis Patients: Monitored with Cardiac MR Elastography

Arvin Arani1, Jessica Magnuson1, Joshua D. Trzasko1, Yi Sui1, Kevin J. Glaser1, Armando Manduca1, Richard L. Ehman1, Sudhakar K. Venkatesh1, and Philip A. Araoz1
1Mayo Clinic, Rochester, MN, United States

Light chain (AL) cardiac amyloidosis is a disease where abnormal proteins are deposited in the heart tissue, commonly resulting in elevated myocardial stiffness. In cases with poor prognosis, autologous hematopoietic stem cell transplantation is used as a therapy. However, organ response monitoring is currently limited and challenging. The goal of this study is to evaluate the feasibility of using cardiac magnetic resonance elastography (MRE) to monitor changes in left ventricular (LV) myocardial stiffness after stem cell transplantation for treatment of AL amyloidosis. MRE detected a statistically significant (p=0.007) decrease in LV stiffness (mean decrease: 1.6±0.7 kPa, 17.0±7.4%) post therapy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here