Abstract #0031

Regional Brain Mechanical Properties Throughout Maturation from Childhood to Adulthood

Grace McIlvain ¹, Julie M Schneider², Melanie A Matyi ³, Melissa S DiFabio¹, Peyton L Delgorio¹, Matthew DJ McGarry ⁴, Jeffrey M Spielberg³, Zhenghan Qi², and Curtis L Johnson¹

¹Biomedical Engineering, University of Delaware, Newark, DE, United States, ²Department of Linguistics, University of Delaware, Newark, DE, United States, ³Department of Psychology, University of Delaware, Newark, DE, United States, ⁴Thayer School of Engineering, Dartmouth College, Hanover, NH, United States

Brain mechanical properties are markers of microstructural health and have been extensively studied in neurodegeneration using MR elastography. However, brain mechanical changes during maturation have yet to be comprehensively explored. Here we present preliminary findings from an ongoing study which uses OSCILLATE, a fast acquisition, high-resolution sequence to characterize brain mechanical properties in people ages 5-21. We present notable regional brain mechanical property differences during development and aim to categorize brain mechanical property developmental trajectories in major anatomical structures. This data will provide a platform for brain mechanical property comparison when studying atypical maturation.

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