Abstract #0032

Quantification of in-vivo myocardial stiffness in the rat heart using transient mechanical waves

Anna Sophie Wittgenstein¹, Marco Barbero Mota², Giacomo Annio², Guillaume Rucher², Rachida Aid-Launais², Rami Mustapha³, David Alexander Nordsletten^1,4, and Ralph Sinkus^1,2

¹School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²INSERM-Université de Paris, Paris, France, ³chool of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom, ⁴Department of Biomedical Engineering and Cardiac Surgery, University of Michigan, Ann Habor, MI, United States

In vivo assessment of biomechanical properties in the left ventricle carries substantial promises for disease characterization. Its proper quantification, however, is far from straightforward. We propose an ECG-gated 3D CINE GRE sequence with motion encoding gradients (TR=7ms) and time-shifted mechanical excitation to quantify the propagation of transient shear waves at a temporal resolution of 0.7ms. In-vivo results in anesthetised rats show apparent shear waves speeds around 8m/s at mid diastole, compatible with recent human in-vivo data.

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