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Abstract #0033

Stiffness and Fluidity of Hepatic Fibrosis Elucidated by In Vivo Multifrequency MR Elastography

Rolf Reiter1, Mehrgan Shahryari1, Heiko Tzschätzsch1, Matthias Haas1, Christian Bayerl1, Britta Siegmund2, Bernd Hamm1, Patrick Asbach1, Jürgen Braun1, and Ingolf Sack1
1Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Gastroenterology, Charité - Universitätsmedizin Berlin, Berlin, Germany

We aimed to investigate the solid-fluid behavior of hepatic fibrosis and cirrhosis using multifrequency MR elastography. Despite the success of stiffness-based assessment of hepatic fibrosis, little is known about tissue’s solid-fluid behavior upon fibrosis. Although cirrhosis is associated with liver stiffening and, intuitively, transition towards more rigid material properties, the observed increases in fluidity and slope of shear-wave-speed-dispersion indicate abnormally high mechanical friction in cirrhotic livers. This biophysical signature might provide a prognostic imaging marker for the detection of end-stage fibrosis independent of stiffness.

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