Abstract #0034

Liver Stiffness Measurement by Magnetic Resonance Elastography is not Affected by Hepatic Steatosis

Jie Chen^1,2, Alina Allen³, Terry Therneau⁴, Jun Chen², Jiahui Li², Jingbiao Chen², Xin Lu², Zheng Zhu², safa Hoodeshenas², Sudhakar Venkatesh², Bin Song¹, Richard Ehman², and Meng Yin²

¹Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, ²Department of Radiology, Mayo Clinic, Rochester, MN, United States, ³Devision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States, ⁴Devision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States

In a cross-sectional study, we investigated the relationship between pathology-assessed hepatic steatosis, MRI-assessed PDFF, and LSM with MRE in a large NAFLD population. No significant differences in LSM was found between patients with S1, S2, and S3 steatosis, and between all steatosis grades after patients were grouped according to fibrosis stage. After adjusting with fibrosis stage and age, there was no statistically significant relationship between liver stiffness and PDFF in patients with diagnosed steatosis (i.e., PDFF≥5%). LSM by MRE is not biased by increased liver fat content.

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