Abstract #0035

Tumor stiffness and stiffness change using 3D MR elastography are markers of tumor lymphocyte infiltration and immunotherapy response in HCC.

Paul Kennedy¹, Muhammed Shareef¹, Octavia Bane¹, Guillermo Carbonell¹, Elizabeth Miller², Israel Lowy², Stephen Ward¹, M. Isabel Fiel¹, Miriam Merad¹, Thomas Marron¹, and Bachir Taouli¹

¹Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Regeneron Pharmaceuticals Inc., Tarrytown, NY, United States

In this prospective study we correlated tumor stiffness measured in hepatocellular carcinoma with density of tumor infiltrating lymphocytes and assessed the changes in tumor stiffness in patients undergoing neoadjuvant immunotherapy prior to liver resection. We found that tumor stiffness strongly correlates with grade of tumor infiltrating lymphocytes, and that changes in tumor stiffness correlate with histopathologic response.

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