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Abstract #0035

Tumor stiffness and stiffness change using 3D MR elastography are markers of tumor lymphocyte infiltration and immunotherapy response in HCC.

Paul Kennedy1, Muhammed Shareef1, Octavia Bane1, Guillermo Carbonell1, Elizabeth Miller2, Israel Lowy2, Stephen Ward1, M. Isabel Fiel1, Miriam Merad1, Thomas Marron1, and Bachir Taouli1
1Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Regeneron Pharmaceuticals Inc., Tarrytown, NY, United States

In this prospective study we correlated tumor stiffness measured in hepatocellular carcinoma with density of tumor infiltrating lymphocytes and assessed the changes in tumor stiffness in patients undergoing neoadjuvant immunotherapy prior to liver resection. We found that tumor stiffness strongly correlates with grade of tumor infiltrating lymphocytes, and that changes in tumor stiffness correlate with histopathologic response.

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