Abstract #0045

Evaluation of T1 and T2 from MR Fingerprinting as Markers for Predicting Patient Recovery in Mild Traumatic Brain Injury

TERESA GERHALTER¹, Martijn Cloos², Seena Dehkharghani¹, Anna M. Chen¹, Rosermary Peralta¹, Fatemeh Adlparvar¹, James S. Babb¹, Tamara Bushnik³, Jonathan M. Silver⁴, Brian S. Im³, Stephen P. Wall⁵, Guillaume Madelin¹, and Ivan Kirov¹

¹Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, NEW YORK, NY, United States, ²Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ³Department of Rehabilitation Medicine, New York University Grossman School of Medicine, NEW YORK, NY, United States, ⁴Department of Psychiatry, New York University Grossman School of Medicine, NEW YORK, NY, United States, ⁵Ronald O. Perelman Department of Emergency Medicine, New York University Grossman School of Medicine, NEW YORK, NY, United States

We analyzed brain MRI data including clinical imaging and MR fingerprinting (MRF) of 22 mild traumatic brain injury (mTBI) patients measured ~1 month after injury and 18 healthy controls. T1 and T2 values in mTBI were not significantly different from controls’. However, increased T1 of three brain regions enabled the identification of non-recovered patients at 3-months (AUC=0.80-0.88). This suggests that T1 quantification is more sensitive to mTBI damage than T2, and is a potential candidate to predict patient outcome.

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