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Abstract #0044

Assessing the impact of cerebro-cerebellar and long association fibers in Temporal Lobe Epilepsy: a tractography based study

Nicolò Rolandi1, Fulvia Palesi1,2, Francesco Padelli3, Isabella Giachetti3, Domenico Acquino3, Paul Summers4, Giancarlo Germani4, Gerardo Salvato1,5,6, Valeria Mariani5, Pina Scarpa5,6, Egidio D'Angelo1,2, Gabriella Bottini1,5,6, Laura Tassi5, Paolo Vitali4,7, and Claudia Angela Michela Gandini Wheeler-Kingshott1,2,8
1Department of Brain and Behavioral Science, University of Pavia, Pavia, Italy, 2Brain Connectivity Center Research Deparment, IRCCS Mondino Foundation, Pavia, Italy, 3I.R.C.C.S. Istituto Neurologico Carlo Besta, Milano, Italy, 4Neuroradiology Unit, IRCCS Mondino Foundation, Pavia, Italy, 5Hospital Niguarda, Milano, Italy, 6Milan Center for Neuroscience, Milano, Italy, 7Department of Radiology, IRCCS Policlinico San Donato, Milano, Italy, 8NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of brain Sciences, University College London (UCL), London, United Kingdom

Advance tractography were performed on cerebro-cerebellar and long association fibers, characterized with diffusion tensor imaging, diffusion kurtosis imaging and NODDI parameter maps. The aim of this work is investigate whether white matter alterations of specific tracts can be selectively related to disfunction of declarative long term memory. Our findings show how relationship between microstructural alterations and neuropsychological scores should be investigated taking account in specific area of white matter restriced to tracts or bundle.

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