Abstract #0044

Assessing the impact of cerebro-cerebellar and long association fibers in Temporal Lobe Epilepsy: a tractography based study

Nicolò Rolandi¹, Fulvia Palesi^1,2, Francesco Padelli³, Isabella Giachetti³, Domenico Acquino³, Paul Summers⁴, Giancarlo Germani⁴, Gerardo Salvato^1,5,6, Valeria Mariani⁵, Pina Scarpa^5,6, Egidio D'Angelo^1,2, Gabriella Bottini^1,5,6, Laura Tassi⁵, Paolo Vitali^4,7, and Claudia Angela Michela Gandini Wheeler-Kingshott^1,2,8

¹Department of Brain and Behavioral Science, University of Pavia, Pavia, Italy, ²Brain Connectivity Center Research Deparment, IRCCS Mondino Foundation, Pavia, Italy, ³I.R.C.C.S. Istituto Neurologico Carlo Besta, Milano, Italy, ⁴Neuroradiology Unit, IRCCS Mondino Foundation, Pavia, Italy, ⁵Hospital Niguarda, Milano, Italy, ⁶Milan Center for Neuroscience, Milano, Italy, ⁷Department of Radiology, IRCCS Policlinico San Donato, Milano, Italy, ⁸NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of brain Sciences, University College London (UCL), London, United Kingdom

Advance tractography were performed on cerebro-cerebellar and long association fibers, characterized with diffusion tensor imaging, diffusion kurtosis imaging and NODDI parameter maps. The aim of this work is investigate whether white matter alterations of specific tracts can be selectively related to disfunction of declarative long term memory. Our findings show how relationship between microstructural alterations and neuropsychological scores should be investigated taking account in specific area of white matter restriced to tracts or bundle.

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