Abstract #0043

Brain metabolic impairment after mild repetitive traumatic brain injury can be measured by hyperpolarized [1-13C]pyruvate and [13C]urea

Caroline Guglielmetti^1,2, Kai Qiao^1,2, Brice Tiret^1,2, Karen Krukowski^1,3, Amber Nolan^3,4, Susanna Rosi^1,3,5,6, and Myriam M. Chaumeil^1,2

¹Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States, ²Department of Radiology and Biomedical Sciences, University of California San Francisco, San Francisco, CA, United States, ³Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, United States, ⁴Department of Pathology, University of California San Francisco, San Francisco, CA, United States, ⁵Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States, ⁶Weill institute for Neuroscience, University of California San Francisco, San Francisco, CA, United States

We used hyperpolarized ¹³C magnetic resonance spectroscopic imaging (HP ¹³C MRSI), T1- and T2-MRI to detect brain alterations in a mouse model of mild repetitive traumatic brain injury (rTBI). T1/T2-MRI did not detect brain damages. HP ¹³C MRSI detected metabolic changes in cortical areas, with decreased HP lactate/pyruvate and pyruvate dehydrogenase activity in rTBI. Interestingly, HP pyruvate and HP urea increased in rTBI, suggesting vascular and/or blood brain barrier alterations. Altogether, we demonstrated that HP ¹³C MRSI has potential to detect long-lasting metabolic alterations following rTBI and holds great potential for improving diagnosis and monitoring of rTBI in clinical practice.

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