Abstract #0047

Measurement of Blood-Brain Barrier Disruption in Cats with an Inherited Neurodevelopmental Abnormality using Magnetization Transfer-ASL at 7T

Sultan Zaman Mahmud^1,2, Emily C. Graff^3,4, Douglas R. Martin^4,5, Thomas S. Denney^1,2, and Adil Bashir^1,2

¹Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, ²Auburn University MRI Research Center, Auburn University, Auburn, AL, United States, ³Department of Pathobiology, Auburn University, Auburn, AL, United States, ⁴Scott-Ritchey Research Center, Auburn University, Auburn, AL, United States, ⁵Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, United States

The blood-brain barrier (BBB) plays a vital role in regulating nutrient transport and acts as a barrier to potentially harmful molecules. Disruption of the BBB alters normal neurodevelopment and neuronal function. Protein enriched in astrocytes 15-kDa (PEA15) is crucial in normal neurodevelopment of cats, and cats with a PEA15 loss-of-function (PEA15^-/-) have structural brain abnormalities and behavioral defects. We have previously demonstrated a non-invasive MRI technique to measure BBB permeability in humans. The goal of this study is to investigate if this technique can detect differences in microvascular cerebral blood flow and BBB in PEA15^-/- cats compared to PEA15^+/+.

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