Abstract #0048

MR Multitasking-based Dynamic Imaging for Cerebrovascular Evaluation (MT-DICE): Further Development and Feasibility Study on Brain Cancer

Zhehao Hu^1,2, Anthony Christodoulou^1,2, Nan Wang¹, Yibin Xie¹, Tianle Cao^1,2, Marcel Maya³, Wensha Yang⁴, Debiao Li^1,2, and Zhaoyang Fan^1,4,5

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁵Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

DSC-MRI and DCE-MRI provide perfusion- and permeability-related parameters, respectively, and are evolving as increasingly common modalities for evaluating a variety of brain cancer diseases. Their different but complementary information may form a more complete basis for evaluation of the complex and heterogeneous tumor microenvironment. However, acquiring both in one exam requires two separate scans as well as two contrast injections. In this work, we propose an MR MultiTasking based Dynamic Imaging for Cerebrovascular Evaluation (MT-DICE) technique that provides DCE- and leakage-corrected DSC-MRI parameters simultaneously with one 7.6-minute scan and a single-dose contrast injection.

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